Just stay away from cruise ship destinations. If you're a clear tourist, people will think you just got off a random boat and are only there for a few hours so they'll treat you as such. (Try to sell you stuff aggressively, may make you a target of crime with the assumption you have to leave the location soon and won't report it, etc).
If you're going to Amsterdam for the reasons @
AThomasHowe mentioned... just come to the USA and go to Colorado... Has all the stuff you want plus has mountains and beautiful scenery... Can go skiing, snowboarding, hiking, biking, or whatever floats your boat... because there is also rivers with rapids! Colorado rocks!
But the real question is, what do you want to do? My idea of a vacation and yours may differ. I want tune out. I want to relax. I want to sit on a beach and stare into nothingness as I sip rum from a coconut without a worry in the world. I want to see old ruins of yesteryear and see someplace scenic. I want to go camping and be without internet so I can relax. Cities don't really interest me all that much.
With that said, in the USA, places of notable interest would be of course: The Grand Canyon, Colorado Rockies, Smokey Mountain National Park (In Tennessee), I love the desert... so, the American south west is amazing. Go book a room in Vegas, party on the strip, rent a car and hit up the Valley of Fire national park, drive across the Hoover Dam and have some fun.
NYC and LA, never really interested me that much but people seem to like them. I may plan a NYC trip one day just to say I've been and to see the normal monument stuff like the Empire State Building, Statue of Liberty, and what not.
Personally haven't spent much time outside of the US... but last year spent a couple weeks in Nassau which was alright, but see what I mentioned above about cruise ship destinations... Beautiful island and beaches, but I could do without the non-stop harassment and people trying to sell me shit.
Despite not liking 'cruise ship destinations'... as in, flying or staying in one for any amount of time... I actually
do like cruises. You get fed well, you get to lay out in the sun drinking liquour and just relaxing. Then you wake up the next morning and you're docked in some nice place, you get off and walk around for a few hours, buy some shot glasses and shirts and take some pictures and get back on the boat and just relax until the next destination. It's great.
I've been wanting to do a SE Asia trip for a while myself. Thailand, Vietnam, Cambodia, and Malaysia. To me, it appears to offer pretty much what I look for in a travel destination. Nice beaches to relax by. Beautiful nature to submerge myself in. Cheap food and transportation once there. Amazing old temples and architectural ruins. In fact I was previously looking at getting my TEFL (Teaching English as a Foreign Language) certification simply so I could live in Thailand in Chiang Mai (I'm not a big fan of big cities, so Bangkok I'd likely avoid) where I could teach English, live cheap, earn extra money doing internet stuff and just use my teaching job as a means of having a work visa to stay there as long as possible.
Other places of interest: New Zealand, Tonga, Fiji, etc (really any island in the south pacific that wasn't a test site for nuclear missiles). Spain, Chile, Peru (Machu Picchu), etc.
Though if you pass through Indiana or take a wrong turn and find yourself here for some odd reason, hit me up. We'll go to the shooting range and do other American things like eat burgers and drink beers!